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Updated: Jun 7, 2026

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
Published on: June 11, 2019
Left atrial thrombus masquerading as a myxoma in a patient with mitral stenosis
Sobhan Kodali1, June Yamrozik, Robert W W Biederman
1Division of Cardiology, Gerald McGinnis Cardiovascular Institute, Allegheny General Hospital, Drexel University College of Medicine, Pittsburgh, Pennsylvania, USA. shoban.kodali@gmail.com
Insights
Differentiating left atrial appendage thrombi from myxomas preoperatively can be challenging. This case demonstrates how an organized thrombus can mimic a myxoma on cardiac MRI, leading to misdiagnosis.
Area of Science:
- Cardiology
- Cardiovascular Imaging
Background:
- Preoperative differentiation between left atrial appendage thrombus and myxoma is clinically significant but often difficult.
- Standard clinical and echocardiographic features may not reliably distinguish these conditions.
Observation:
- A patient presented with a left atrial appendage thrombus.
- The thrombus was misdiagnosed as a myxoma based on cardiac magnetic resonance imaging characteristics.
- Coronary angiography revealed dense neovascularization, which contributed to the misdiagnosis.
Findings:
- The organized thrombus exhibited imaging features mimicking a myxoma.
- Neovascularization on coronary angiography further supported the misdiagnosis of myxoma.
Implications:
- This case underscores the potential for organized thrombi to present with atypical features that resemble myxomas.
- Enhanced awareness and advanced imaging interpretation are crucial for accurate preoperative diagnosis.
- Improved diagnostic strategies are needed to avoid misclassification and ensure appropriate patient management.
Abstract:
The preoperative differentiation of a thrombus from a myxoma is important but not always easy. Clinical and echocardiographic characteristics of myxoma and thrombi are not diverse enough to always reliably distinguish the two. We report the case of a patient who was found to have a left atrial appendage thrombus that was misdiagnosed as a myxoma on the basis of its imaging characteristics on cardiac magnetic resonance in addition to the detection of dense neovascularization on coronary angiography. This case highlights the unusual features of an organized thrombus that can mimic many of the distinguishing characteristics of a myxoma.
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