Related Experiment Video
Updated: Jun 7, 2026
12:02
Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
Published on: July 30, 2016
Maternal plasma total antioxidant status in preterm labor
Aysegül Cinkaya1, Hüseyin Levent Keskin, Umran Buyukkagnici
1Department of High Risk Pregnancy Laboratory, Zekai Tahir Burak Education and Research Hospital, Ankara, Turkey.
The Journal of Obstetrics and Gynaecology Research
|November 3, 2010
Summary
Women experiencing preterm labor have lower total antioxidant status (TAS) compared to those with uncomplicated pregnancies. This suggests a potential link between reduced antioxidant capacity and the onset of preterm labor.
Area of Science:
- Obstetrics and Gynecology
- Biochemistry
- Reproductive Medicine
Background:
- Oxidative stress is implicated in various pregnancy complications.
- Antioxidant status plays a crucial role in maintaining physiological balance during pregnancy.
Purpose of the Study:
- To investigate the association between oxidative stress and antioxidant status in women with preterm labor.
- To compare the total antioxidant status (TAS) in preterm labor cases versus uncomplicated pregnancies.
Main Methods:
- A case-control study involving 25 women with preterm labor and 25 women with uncomplicated pregnancies.
- Maternal plasma total antioxidant status (TAS) was measured using a Hitachi 911 autoanalyzer and a commercial kit.
Main Results:
- Mean serum TAS was significantly lower in the preterm labor group (1.002 ± 0.177 mmol/L) compared to the control group (1.258 ± 0.147 mmol/L).
- The difference in TAS between the groups was statistically significant (P < 0.001).
Conclusions:
- Preterm labor is associated with decreased total antioxidant status.
- Further prospective studies are warranted to determine if reduced TAS is a precursor to preterm labor.
