Related Experiment Video
Updated: Jun 7, 2026
07:55
Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice
Published on: August 4, 2011
Phthisis bulbi in retinoblastoma
Seema Kashyap1, Rachna Meel, Neelam Pushker
1Ocular Pathology Services, New Delhi, India.
Clinical & Experimental Ophthalmology
|November 3, 2010
Summary
Phthisis bulbi is an uncommon presentation of retinoblastoma, often occurring in both eyes and frequently with advanced disease in the fellow eye. Incomplete regression necessitates enucleation for all such cases.
Area of Science:
- Ophthalmology
- Pediatric Oncology
- Retinal Diseases
Background:
- Phthisis bulbi is an uncommon and atypical clinical presentation of retinoblastoma.
- Retinoblastoma is a malignant tumor of the retina.
Purpose of the Study:
- To analyze the clinical, imaging, and histopathological features of retinoblastoma patients with primary phthisis bulbi.
- To determine the association of phthisis bulbi with disease laterality and fellow eye status in retinoblastoma.
Main Methods:
- Retrospective analysis of 18 consecutive retinoblastoma patients with primary phthisis bulbi.
- Evaluation of clinical, imaging (CT scan), and histopathological findings.
- Data collected between January 2005 and December 2009 at a tertiary care hospital.
Main Results:
- 18.3% of retinoblastoma patients presented with primary phthisis bulbi.
- 83% of cases had bilateral disease, with 80% of those having advanced intraocular disease in the fellow eye.
- Incomplete tumor regression was noted in 67% of eyes, with high-risk factors present in 33%.
Conclusions:
- Phthisis bulbi in retinoblastoma is frequently associated with bilateral involvement and advanced disease in the contralateral eye.
- Incomplete regression is common, underscoring the need for enucleation in all retinoblastoma cases presenting with phthisis bulbi.
Related Concept Videos
01:20The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:20The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
01:22Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...