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A rapid infusion protocol is safe for total dose iron polymaltose: time for change
M Garg1, G Morrison, A Friedman
1Department of Gastroenterology and Hepatology, Eastern Health, Melbourne, Victoria, Australia.
Internal Medicine Journal
|November 3, 2010
Summary
Rapid intravenous iron polymaltose infusion is safe and preferred by patients. This faster method reduces hospital strain and offers significant time and cost benefits.
Area of Science:
- Internal Medicine
- Pharmacology
Background:
- Traditional intravenous iron polymaltose protocols are lengthy (>4 hours), impacting patient acceptance and hospital resources.
- Iron deficiency anemia requires effective and efficient treatment strategies.
Purpose of the Study:
- To prospectively evaluate the safety and patient acceptance of a rapid intravenous iron polymaltose infusion protocol.
- To compare the rapid infusion protocol with historical data for slow infusions.
Main Methods:
- 100 patients received up to 1.5 g of iron polymaltose via a 58-minute infusion after a 15-minute test dose.
- Infusion-related and delayed adverse events were prospectively documented and graded.
Main Results:
- 24 patients experienced 34 infusion-related adverse events (25 mild, 8 moderate, 1 severe).
- 26 patients experienced 31 delayed adverse events (26 mild, 3 moderate, 2 severe).
- Inflammatory bowel disease (IBD) was associated with higher infusion-related reactions (54% vs 14%).
Conclusions:
- Rapid total dose iron polymaltose infusion is safe and well-accepted by patients.
- This protocol offers significant benefits in cost, resource utilization, and time for patients and healthcare systems.
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