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Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jun 7, 2026

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

The platelet contribution to cancer progression.

N M Bambace1, C E Holmes

  • 1Division of Hematology and Oncology, Department of Medicine, University of Vermont, Burlington, VT 05401, USA.

Journal of Thrombosis and Haemostasis : JTH
|November 3, 2010
PubMed
Summary

Platelets, traditionally known for blood clotting, are increasingly recognized for their role in cancer progression and metastasis. Targeting platelet interactions offers a promising new avenue for cancer therapy.

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Last Updated: Jun 7, 2026

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
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Area of Science:

  • Oncology
  • Hematology
  • Cancer Biology

Background:

  • Platelets are traditionally linked to hemostasis and thrombosis.
  • Emerging research highlights platelet involvement in cancer progression, growth, and dissemination.
  • Complex interactions between platelets and tumor cells are crucial in cancer development.

Purpose of the Study:

  • To explore the multifaceted role of platelets in cancer, including metastasis and angiogenesis.
  • To investigate the potential of targeting platelet-tumor interactions for cancer therapy.
  • To examine the bidirectional relationship between platelets and tumors.

Main Methods:

  • Review of existing literature on platelet biology and cancer.
  • Analysis of experimental data on platelet receptor blockade (e.g., GP1b/IX/V, GPIIbIIIa, GPVI).
  • Discussion of platelet's role as reservoirs for pro- and anti-angiogenic factors.

Main Results:

  • Platelets facilitate cancer growth and metastasis by providing a procoagulant surface and shielding tumor cells from immune responses.
  • Blockade of specific platelet receptors has shown potential in attenuating metastases.
  • Platelets act as reservoirs for proteins influencing angiogenesis, offering pharmacological manipulation targets.

Conclusions:

  • Platelets significantly contribute to cancer progression and metastasis through various mechanisms.
  • Targeting platelet receptors and their interactions with tumor cells presents a promising therapeutic strategy.
  • Platelet inhibitors may influence malignancy progression, warranting clinical investigation.