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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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Hepatitis C treatment: current and future perspectives.

Saira Munir1, Sana Saleem, Muhammad Idrees

  • 1National Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.

Virology Journal
|November 3, 2010
PubMed
Summary
This summary is machine-generated.

Hepatitis C virus (HCV) infection affects 175 million globally. Current treatments like pegylated interferon and ribavirin show variable success rates, with new therapies under investigation for better outcomes.

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Area of Science:

  • Hepatology
  • Virology
  • Pharmacology

Background:

  • Hepatitis C virus (HCV) is a major cause of liver disease, infecting 175 million worldwide.
  • Parental transmission is primary, with intravenous drug users at highest risk.
  • Standard interferon and ribavirin were historical treatments with limited efficacy.

Purpose of the Study:

  • To review current and emerging therapies for Hepatitis C virus (HCV) infection.
  • To discuss treatment efficacy, side effects, and predictors of sustained virological response (SVR).
  • To explore novel therapeutic strategies for HCV management.

Main Methods:

  • Review of existing literature on HCV treatment.
  • Analysis of standard and pegylated interferon-based therapies.
  • Exploration of ongoing research into new antiviral compounds and approaches.

Main Results:

  • Pegylated interferon (PEG-INF) with ribavirin achieves 50% SVR for genotype 1 and 80% for genotypes 2 & 3.
  • Standard interferon remains a primary treatment in developing nations due to cost.
  • Pegylated interferon and ribavirin therapy can cause significant side effects, including hematological complications.

Conclusions:

  • Sustained virological response (SVR) is influenced by viral genotype, pretreatment viral load, rapid virological response (RVR), and patient age.
  • Emerging therapies include HCV IRES inhibitors, NS3/NS5a inhibitors, and targeted antiviral therapies.
  • Future treatments may involve caspase inhibitors, anti-fibrotic agents, antibody treatments, and vaccines.