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Related Experiment Videos

[Sweet syndrome in underlying malignancy].

Pauline V van Hirtum1, Mandy Prins, Jaap ten Oever

  • 1Universiteit Maastricht, faculteit Health, Medicine and Life Sciences, the Netherlands. paulinevanhirtum@hotmail.com

Nederlands Tijdschrift Voor Geneeskunde
|November 3, 2010
PubMed
Summary
This summary is machine-generated.

Sweet syndrome, or acute febrile neutrophilic dermatosis, presents variably and can be severe in patients with underlying malignancy. Early recognition and treatment with prednisone led to good responses in two cases.

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Area of Science:

  • Dermatology
  • Oncology
  • Hematology

Background:

  • Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is a rare inflammatory condition.
  • It is often associated with underlying malignancies or infections.
  • Prompt diagnosis and management are crucial due to potential severe clinical manifestations.

Observation:

  • Two male patients, aged 68 and 58, with chronic lymphatic leukemia relapse and renal cell carcinoma, respectively, presented with fever, neutrophilic leukocytosis, and widespread maculopapular exanthema with vesicles.
  • One patient exhibited signs of septic shock.
  • Histological examination confirmed Sweet syndrome in both cases.

Findings:

  • Both patients showed a significant clinical improvement following treatment with prednisone.
  • Despite initial response, one patient experienced progression of their underlying renal cell carcinoma.
  • Histopathology confirmed Sweet syndrome, highlighting its varied presentation.

Implications:

  • Recognizing the diverse clinical spectrum of Sweet syndrome is vital for timely diagnosis and management.
  • The condition can indicate or accompany serious underlying diseases like cancer.
  • Effective treatment with corticosteroids like prednisone can lead to good outcomes, but vigilance for underlying pathology is essential.