Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Plague01:24

Plague

Plague is a highly virulent zoonotic disease caused by Yersinia pestis, a Gram-negative, facultatively anaerobic coccobacillus. This pathogen primarily circulates among rodent populations and is transmitted to humans through the bite of infected fleas. Additional transmission routes include direct contact with infected animal tissue or inhalation of respiratory droplets from individuals with pneumonic plague. These multiple transmission pathways highlight the bacterium’s potential for rapid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Repeated Antigen Exposure on Humoral Tolerance: Antidrug Antibodies After Single-Dose Versus Multi-dose Adalimumab.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2026
Same author

Building equitable foundations: policy solutions to address preschool suspension, expulsion, and exclusion inequities.

Frontiers in psychology·2026
Same author

The acceptability of minimally invasive tissue sampling for cause of death determination in rural South Africa: A qualitative analysis.

PloS one·2026
Same author

The application of treatment response biomarkers in clinical trials for cryptococcosis, invasive aspergillosis and candidiasis.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same author

A cross-sectional survey of stakeholders to inform the update of the British Association of Dermatologists guidelines for the safe and effective prescribing of methotrexate in dermatology.

Clinical and experimental dermatology·2026
Same author

What I Do Now and What I Have Eliminated from My Facelifts: Proceedings of the 2025 ASPS Spring Meeting.

Plastic and reconstructive surgery·2026
Same journal

A Critical Review of Biological Control Strategies for Powdery Mildew of Bhendi (Abelmoschus esculentus L.).

Microbial pathogenesis·2026
Same journal

AroC as a key virulence factor and live-attenuated vaccine target in Pseudomonas plecoglossicida.

Microbial pathogenesis·2026
Same journal

Biological control evaluation of bacteriophage freeze-dried powder against Aeromonas hydrophila infection, based on whey protein/trehalose.

Microbial pathogenesis·2026
Same journal

Eugenol microemulsions exhibit potent activity against drug-resistant diabetic foot ulcer pathogens: Toward nanocomposite-based wound healing applications.

Microbial pathogenesis·2026
Same journal

Quercetin and Carvacrol Act Synergistically to Inhibit Candida albicans Biofilms In Vitro via Membrane Disruption and Oxidative Stress.

Microbial pathogenesis·2026
Same journal

Assessment of antimicrobial potency, biological function, and molecular docking of the synthetic peptide IL-20 against the major aquaculture pathogen Vibrio anguillarum.

Microbial pathogenesis·2026
See all related articles

Related Experiment Video

Updated: Jun 7, 2026

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
12:21

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

Published on: September 28, 2022

Cynomolgus macaque model for pneumonic plague.

Richard Warren1, Hank Lockman, Roy Barnewall

  • 1Battelle Biomedical Research Center, 505 King Ave., Columbus, OH 43201, USA.

Microbial Pathogenesis
|November 3, 2010
PubMed
Summary
This summary is machine-generated.

A cynomolgus macaque model for pneumonic plague was established to test a new vaccine. This model accurately mimics human disease, showing similar pathology and enabling vaccine efficacy studies.

More Related Videos

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
04:32

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

Related Experiment Videos

Last Updated: Jun 7, 2026

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
12:21

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

Published on: September 28, 2022

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
04:32

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

Area of Science:

  • Infectious Diseases
  • Vaccinology
  • Primate Models

Background:

  • Pneumonic plague poses a significant public health threat.
  • A recombinant F1V vaccine is under development for protection.
  • A relevant animal model is crucial for vaccine efficacy evaluation.

Purpose of the Study:

  • To establish a cynomolgus macaque (CM) model for pneumonic plague.
  • To determine the inhaled median lethal dose (LD₅₀) of Yersinia pestis CO92.
  • To characterize disease pathophysiology and identify study endpoints in CMs.

Main Methods:

  • Eighteen CMs were exposed to aerosolized Yersinia pestis CO92 across seven dosages.
  • Median lethal dose (LD₅₀) was calculated using Probit analysis.
  • Disease was assessed via blood culture, clinical pathology, histopathology, and telemetry.

Main Results:

  • The inhaled LD₅₀ was estimated at 24 colony forming units.
  • CMs developed fever, bacteremia, and cardiorespiratory changes preceding death (34-92 hours post-fever onset).
  • Histopathology revealed lung inflammation (neutrophils, fibrinous pleuritis) consistent with pneumonic plague.

Conclusions:

  • The cynomolgus macaque model replicates key aspects of human pneumonic plague.
  • This model is suitable for evaluating the efficacy of the rF1V vaccine candidate.
  • The established model provides a foundation for further pneumonic plague research and countermeasures.