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Epidemiology and burden of rotavirus infection among children in Hangzhou, China

Jin-Tu Lou1, Xiao-Jun Xu, Yi-Dong Wu

  • 1Department of Laboratory, Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310003, PR China.

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|November 3, 2010
PubMed

Insights

Rotavirus is a major cause of diarrhea in young children in Hangzhou. Surveillance data show high infection rates in children under two, emphasizing the need for rotavirus immunization.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Epidemiology

Background:

  • Rotavirus is a leading global cause of acute diarrhea in children under five.
  • Limited data exist on rotavirus diarrhea within outpatient settings.

Purpose of the Study:

  • To determine the epidemiology of rotavirus diarrhea in Hangzhou, China.
  • To assess the burden of diarrhea and rotavirus infection in children.

Main Methods:

  • Conducted systematic surveillance of rotavirus diarrhea from 2007-2008.
  • Analyzed 46,499 stool samples using latex agglutination testing.

Main Results:

  • Rotavirus was detected in 33.7% of samples, with the highest prevalence in children aged 12-24 months.
  • 92.4% of rotavirus infections occurred in children under two years old.
  • Estimated annual rotavirus-associated outpatient visits and hospitalizations were 20.1 and 2.1 per 1000 children under five, respectively.

Conclusions:

  • Rotavirus is the primary cause of severe childhood diarrhea in Hangzhou, particularly in children under two.
  • The findings underscore the importance of widespread rotavirus vaccination for young children.
Abstract

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