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Elevated fibroblast growth factor 23 levels in a newborn with secondary hypoparathyroidism

Anneke Bech1, Karin Nabbe, Wim Brussel

  • 1Department of Internal Medicine, Rijnstate Hospital, Wagnerlaan 55, 6800 TA Arnhem, The Netherlands.

Pediatrics
|November 3, 2010
PubMed

Insights

Fibroblast growth factor 23 (FGF-23) is crucial for phosphate balance. This study reports extremely high FGF-23 levels in a newborn with transient hypoparathyroidism, which normalized over seven months.

Area of Science:

  • Endocrinology
  • Mineral Metabolism
  • Pediatric Endocrinology

Background:

  • Fibroblast growth factor 23 (FGF-23) is a key hormone regulating phosphate homeostasis.
  • FGF-23 influences renal phosphate excretion and vitamin D synthesis.
  • Limited data exists on FGF-23 levels in early infancy.

Purpose of the Study:

  • To investigate FGF-23 levels in a newborn with transient secondary hypoparathyroidism.
  • To understand the physiological significance of FGF-23 in newborns.

Main Methods:

  • Case report of a newborn with transient secondary hypoparathyroidism due to maternal hyperparathyroidism.
  • Measurement of FGF-23 levels at birth and during follow-up.
  • Comparison of FGF-23 levels with maternal and healthy newborn ranges.

Main Results:

  • Newborn presented with extremely high FGF-23 levels at birth (15,850 kRU/L), approximately 45 times higher than the mother's and 7 times higher than healthy newborns.
  • FGF-23 levels gradually decreased, reaching the normal adult range by approximately 7 months of age.
  • Transient secondary hypoparathyroidism was diagnosed in the infant.

Conclusions:

  • This case highlights exceptionally high FGF-23 levels in a newborn with transient secondary hypoparathyroidism.
  • The findings suggest a potential role for FGF-23 in neonatal mineral metabolism and its dynamic changes in early infancy.
  • Further research is needed to elucidate the precise physiological functions of FGF-23 in newborns.

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