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Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

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Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
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Published on: January 31, 2025

Clinical experience with Hedgehog pathway inhibitors.

Jennifer A Low1, Frederic J de Sauvage

  • 1Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|November 3, 2010
PubMed
Summary

The Hedgehog (Hh) signaling pathway is crucial for development but its reactivation drives cancer. Inhibitors targeting this pathway, like GDC-0449, show promise for cancer treatment.

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Published on: November 30, 2021

Area of Science:

  • Oncology
  • Developmental Biology

Background:

  • The Hedgehog (Hh) signaling pathway regulates cell growth and differentiation.
  • Aberrant Hh pathway activation is implicated in various cancers, including basal cell carcinoma and medulloblastoma.
  • Hh signaling can be activated through ligand overexpression or mutations.

Purpose of the Study:

  • To review the role of the Hh signaling pathway in cancer development.
  • To discuss the clinical activity of Hh pathway inhibitors.

Main Methods:

  • Literature review of studies on Hh signaling in cancer.
  • Analysis of clinical data for Hh pathway inhibitors.

Main Results:

  • Hh pathway reactivation is a key mechanism in tumorigenesis.
  • Paracrine Hh signaling and mutations drive tumor growth.
  • Clinical inhibitors like GDC-0449 targeting Smoothened (SMO) are under investigation.

Conclusions:

  • Targeting the Hh pathway is a promising therapeutic strategy for various cancers.
  • Understanding Hh pathway's role in different tumor types is critical for effective treatment development.