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Related Concept Videos

Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Angina II: Classification01:27

Angina II: Classification

Angina, also known as angina pectoris, is a chest pain resulting from diminished blood flow to the heart muscle and is often a symptom of coronary artery disease. Angina presents several variants with distinctive attributes, etiologies, and therapeutic approaches. The main types of angina include stable, unstable, variant (Prinzmetal's), microvascular, intractable, and silent ischemia.Stable angina is caused by atherosclerosis, which leads to the formation of plaques that narrow the coronary...
Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...

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Related Experiment Video

Updated: Jun 7, 2026

Quantifying Pain Location and Intensity with Multimodal Pain Body Diagrams
09:00

Quantifying Pain Location and Intensity with Multimodal Pain Body Diagrams

Published on: July 7, 2023

What is this thing called pain?

Clifford J Woolf1

  • 1Department of Neurology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA. clifford.woolf@childrens.harvard.edu

The Journal of Clinical Investigation
|November 3, 2010
PubMed
Summary
This summary is machine-generated.

Scientists are unraveling the complex mystery of pain by studying the genes, molecules, cells, and circuits involved. This research offers new hope for better pain management strategies.

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Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

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Determining heat and mechanical pain threshold in inflamed skin of human subjects

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Related Experiment Videos

Last Updated: Jun 7, 2026

Quantifying Pain Location and Intensity with Multimodal Pain Body Diagrams
09:00

Quantifying Pain Location and Intensity with Multimodal Pain Body Diagrams

Published on: July 7, 2023

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

Determining heat and mechanical pain threshold in inflamed skin of human subjects
13:21

Determining heat and mechanical pain threshold in inflamed skin of human subjects

Published on: January 14, 2009

Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Pain is a complex sensation with profound impact on quality of life.
  • Understanding the underlying mechanisms of pain has been a long-standing challenge.

Purpose of the Study:

  • To review recent advancements in understanding the biological basis of pain.
  • To highlight new opportunities for pain management based on scientific progress.

Main Methods:

  • Review of current scientific literature on pain research.
  • Synthesis of findings from genetics, molecular biology, and neuroscience.

Main Results:

  • Significant progress has been made in identifying key genes, molecules, cells, and neural circuits involved in pain perception.
  • These discoveries are paving the way for novel therapeutic approaches.

Conclusions:

  • The mystery of pain is gradually being solved through interdisciplinary research.
  • Advances in understanding pain mechanisms offer promising avenues for improved pain management.