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Updated: Jun 7, 2026

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
Published on: June 8, 2017
Posterior reversible encephalopathy syndrome in neuro-malaria
Alexis Lacout1, Celine Guidoux, Robert Yves Carlier
1Department of Radiology, Centre d'imagerie Médicale, Centre Médico Chirurgical (CMC) - groupe VITALIA 83, Avenue Charles de, Gaulle 15000, Aurillac, France.
Abstract:
We report a case of a 37-year-old patient with Plasmodium falciparum infestation who developed posterior reversible encephalopathy. In cerebral malaria, microscopic studies have shown endothelial dysfunction and disruption of the blood-brain barrier. Data from the literature show that one of the mechanisms of posterior reversible encephalopathy may be capillary leakage and acute disruption of the blood-brain barrier. Our case supports the theory of blood-brain barrier disruption being a key factor in the causation of cerebral malaria.
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