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The initial step in human immunodeficiency virus type 1 GagProPol processing can be regulated by reversible oxidation

Sarah I Daniels1, David A Davis, Erin E Soule

  • 1HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

Plos One
|November 3, 2010
PubMed
Summary

Reversible oxidation of HIV-1 protease cysteines in GagProPol precursors inhibits viral maturation. This process can be reversed, offering a potential regulatory mechanism for retroviral processing and maturation.

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