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Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
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[Prophylaxis in haemophilia B. Prevention of bleeds and FIX consumption]

B Siegmund1, H Richter, H Pollmann

  • 1Institut für Thrombophilie und Hämostaseologie, Praxis Dr. med. Hartmut Pollmann, Loerstraße 19, 48143 Münster. ith@haemophilie-zentrum.de

Hamostaseologie
|November 3, 2010
PubMed

Based on the documentation from patients with severe haemophilia B (FIX:C <1%) in home treatment the positive effect of continuous prophylaxis compared to on demand treatment was investigated over one year in a retrospective study from a single treatment centre (Centre for Haemostaseology Muenster). The advantage of the reduction in the number of bleeding episodes by 90% was opposed by a threefold higher consumption of FIX concentrates and a fourfold higher exposure of the patients to intravenous injections.

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