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Updated: Jun 7, 2026

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
Published on: September 30, 2021
[When is severe haemophilia A diagnosed in children and when do they start to bleed? Re-evalution after 10 years of
H Pollmann1, B Siegmund, H Richter
1Institut für Thrombophilie und Hämostaseologie, Praxis Dr. med. Hartmut Pollmann, Loerstraße 19, 48143 Münster. ith@haemophilie-zentrum.de
Unlabelled:
Based on a previous investigation, the aim of this study was to re-evaluate when children with severe haemophilia A (FVIII:C <1%) are diagnosed and when they start to bleed. Data from previously untreated patients (n = 20) were collected.
Results:
95% of the patients experienced their first bleeding episode at the age of less than one year. On average, the first non-joint bleed occurred at the age of 0.85 years, whereas the first joint bleed developed approximately a half year later at the age of 1.49 years. Compared to the previous investigation children were diagnosed earlier, i.e. at the age of 3.7 month on average.
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