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Structure and Function of Platelets01:18

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Microfluidics in Assessing Platelet Function
06:47

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Published on: November 8, 2024

Platelet function in obese children and adolescents.

J Lohse1, J Schweigel, A Naeke

  • 1Department of Paediatric Hematology and Oncology, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstr. 74, D-01307 Dresden, Germany. judith.lohse@uniklinikum-dresden.de

Hamostaseologie
|November 3, 2010
PubMed
Summary

Obese children with lipometabolic disorders show increased platelet aggregation in whole blood, indicating a hypercoagulable state. This heightened platelet activity may contribute to thromboembolic events in childhood obesity.

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Area of Science:

  • Pediatrics
  • Hematology
  • Metabolic disorders

Background:

  • Platelet hyperaggregability is linked to thromboembolic events in adult obesity.
  • Previous studies noted hyperaggregability in platelet-rich plasma of obese children.

Purpose of the Study:

  • To investigate platelet aggregation in whole blood in children with obesity and lipometabolic disorders.
  • To determine if whole blood platelet aggregation differs in obese children with metabolic issues.

Main Methods:

  • Whole blood aggregation and ATP release were measured in overweight children, normal weight hypercholesterolemia patients, overweight patients with lipometabolic disorders, and healthy controls.
  • Platelet aggregation was induced using ADP, collagen, and thrombin.
  • A lumiaggregometer was used for measurements.

Main Results:

  • No significant differences in platelet aggregation were found in overweight children or normal weight hypercholesterolemia patients compared to controls.
  • Patients with obesity and combined lipometabolic disorders showed significantly higher platelet aggregation rates (p < 0.05).
  • This suggests a hyperaggregable state in obese children with lipometabolic disorders.

Conclusions:

  • Obese children, particularly those with lipometabolic disorders, exhibit a hypercoagulable state.
  • Slight hyperaggregability in whole blood may contribute to this hypercoagulable state.
  • Preventing childhood obesity is crucial, especially in regions with rising prevalence.