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[Evaluation of haemostasis in children treated with valproic acid]

D Schädlich1, D Friebel, J Schallner

  • 1Universitätsklinikum Carl Gustav Carus Dresden, Klinik und Poliklinik für Kinder- und Jugendmedizin, Bereich Hämatologie, Onkologie und Hämostaseologie, Fetscherstr. 74, 10309 Dresden, Germany. ralf.knoefler@uniklinikum-dresden.de

Hamostaseologie
|November 3, 2010
PubMed

Insights

Valproic acid therapy in children showed minimal impact on coagulation, with only a few cases experiencing bleeding. Extended coagulation diagnostics are recommended before surgery for these patients.

Area of Science:

  • Pediatric Hematology
  • Pharmacology
  • Clinical Chemistry

Context:

  • Valproic acid is commonly used for epilepsy and bipolar disorder in children.
  • The combination of valproic acid with lamotrigine is also frequently prescribed.
  • The hemostatic effects of these therapies in pediatric populations require thorough investigation.

Purpose:

  • To evaluate the impact of valproic acid monotherapy and combination therapy with lamotrigine on coagulation parameters in children.
  • To assess bleeding symptoms in pediatric patients undergoing these treatments.

Summary:

  • This study compared coagulation parameters in children on valproic acid monotherapy, valproic acid-lamotrigine combination therapy, and a control group.
  • While most coagulation tests showed no significant differences, the combination therapy group exhibited prolonged closure times (CT).
  • Platelet counts were lower in the monotherapy group, and mild bleeding tendencies were observed in a few children.

Impact:

  • Valproic acid therapy generally has a clinically insignificant effect on hemostasis in most pediatric cases.
  • Extended coagulation diagnostics are advised prior to surgical procedures for children on valproic acid.
  • This research contributes to understanding the safety profile of valproic acid in pediatric patients regarding bleeding risk.
Abstract

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