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Transplantation tolerance with monoclonal antibodies
1Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, UK.
Seminars in Immunology
|November 1, 1990
Summary
Monoclonal antibodies (Mabs) are key tools for immune system manipulation in transplantation. Research explores their use in immunotherapy to induce tolerance in organ graft recipients, improving outcomes.
Area of Science:
- Immunology
- Transplantation Science
- Immunotherapy
Background:
- Monoclonal antibodies (Mabs) are versatile immune system modulators.
- Their effects depend on specificity, structure, and mechanism.
- MAbs are clinically used to prevent graft rejection.
Purpose of the Study:
- To explore novel immunotherapy approaches for inducing transplantation tolerance.
- To investigate the role of Mabs in achieving tolerance in vascularised organ grafts.
Main Methods:
- Utilizing Mabs for immune response modulation.
- Developing Mabs for immunotherapy applications.
Main Results:
- MAbs can trigger, amplify, or suppress immune responses.
- MAbs show success in treating graft rejection.
- New Mabs offer potential for inducing tolerance.
Conclusions:
- Monoclonal antibodies are crucial for immune regulation in transplantation.
- Further development of Mabs holds promise for inducing graft tolerance.