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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Related Experiment Video

Updated: Jun 7, 2026

Isolating Mesangiogenic Progenitor Cells (MPCs) from Human Bone Marrow

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Published on: July 15, 2016

Human embryonic stem cell-derived mesenchymal progenitors: an overview.

Peiman Hematti¹

¹Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, USA.

Methods in Molecular Biology (Clifton, N.J.)

|November 3, 2010

Summary

Human embryonic stem cells (hESCs) can generate mesenchymal stem cells (MSCs) with properties similar to bone marrow-derived MSCs. These hESC-derived MSCs offer a promising, unlimited source for regenerative medicine and tissue reconstruction.

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Published on: October 8, 2016

Area of Science:

Stem Cell Biology
Developmental Biology
Regenerative Medicine

Background:

Mesenchymal stromal/stem cells (MSCs) are multipotent cells found in various tissues, capable of differentiating into bone, cartilage, and fat.
MSCs can also differentiate into non-mesenchymal cell types and contribute to tissue regeneration.
Recent advancements allow derivation of MSCs from human embryonic stem cells (hESCs).

Purpose of the Study:

To investigate the potential of hESCs as a source for MSC generation.
To compare hESC-derived MSCs with bone marrow-derived MSCs.
To explore the therapeutic applications of hESC-derived MSCs.

Main Methods:

Derivation of MSCs from hESCs using various methodologies.
Characterization of hESC-derived MSCs.
Comparison of hESC-derived MSCs with adult tissue-derived MSCs.

Main Results:

hESC-derived MSCs exhibit characteristics similar to bone marrow-derived MSCs.
hESCs provide a scalable and potentially unlimited source for MSC production.
hESC-derived MSCs demonstrate potential for tissue regeneration and immunomodulation.

Conclusions:

Generation of MSCs from hESCs is feasible and yields cells with MSC-like properties.
hESC-derived MSCs represent a valuable resource for studying mesenchymal lineage development.
hESC-derived MSCs hold significant promise for future clinical applications in regenerative medicine and tissue engineering.