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Related Experiment Video

Updated: Jun 7, 2026

Reproducibility and Harmonization in Research Using Biological Standards: The Example of Platelet Agonist Collagen-Related Peptide

Reproducibility and Harmonization in Research Using Biological Standards: The Example of Platelet Agonist Collagen-Related Peptide

Published on: August 4, 2023

Platelet receptors for collagens.

¹University Hospital Muenster, Department of Internal Medicine, Haemostasis Research Laboratory, Domagk-strase 3, D-48129, Muenster, Germany, Tel: +49/251/836180, Fax: + 49/251/836725.

|November 4, 2010

Summary

Platelets interact with vessel wall collagens via specific receptors. Glycoprotein complex Ia/IIa is a major receptor, while CD36 is crucial for collagen type V interactions.

Area of Science:

Biochemistry
Hematology
Vascular Biology

Background:

Collagens in the vessel wall are key determinants of thrombogenicity.
Seven types of collagen (I, III, IV, V, VI, VIII, XIII) are present in vessel walls.
Platelet-collagen interactions are complex, involving adhesion and activation.

Purpose of the Study:

To elucidate the receptors mediating platelet-collagen interactions.
To identify the specific roles of different glycoproteins in these interactions.

Main Methods:

Review of literature on platelet-collagen interactions.
Identification of proposed platelet collagen receptors.

Main Results:

Platelet-collagen interactions involve direct and indirect mechanisms.

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Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Published on: April 6, 2017

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Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Published on: April 6, 2017

Glycoprotein complex Ia/IIa (VLA-2, α2β1 integrin, CD49b/CD29) is a primary receptor for various collagens.

Glycoprotein IIIb (CD36) is implicated in early collagen adhesion, particularly for type V collagen.

P62, a 62 kDa glycoprotein, is another potential collagen receptor.

Conclusions:

Multiple glycoproteins mediate platelet adhesion and aggregation in response to collagen.
Glycoprotein complex Ia/IIa and CD36 are significant platelet collagen receptors with distinct roles.