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Related Experiment Video

Updated: Jun 7, 2026

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

Published on: July 4, 2017

Platelet-derived Growth Factor and its Receptor: Structure and Roles in Normal Growth and Pathology.

L M Khachigian¹, C N Chesterman

¹University of New South Wales Centre for Thrombosis and Vascular Research, The Prince of Wales Hospital, Sydney.

|November 4, 2010

Summary

Platelet-derived growth factor (PDGF) is a key mitogen in development and disease. This review covers PDGF structure, function, and its roles in embryonal development, wound healing, atherosclerosis, and neoplasia.

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Last Updated: Jun 7, 2026

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

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Published on: July 4, 2017

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

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Published on: September 7, 2017

Area of Science:

Biochemistry
Cell Biology
Molecular Biology

Background:

Platelet-derived growth factor (PDGF) is a potent mitogen with critical roles in cellular processes.
PDGF signaling is implicated in both normal physiological functions and various pathological conditions.

Purpose of the Study:

To provide a comprehensive review of Platelet-derived growth factor (PDGF).
To elucidate the structure, function, and regulation of PDGF and its receptors.
To explore the diverse roles of PDGF in embryonal development, wound healing, atherosclerosis, and neoplasia.

Main Methods:

Literature review of existing scientific publications.
Synthesis of information on PDGF structure and function.
Analysis of PDGF's involvement in physiological and pathological contexts.

Main Results:

Detailed overview of PDGF structure and its various isoforms.
Explanation of PDGF receptor binding and downstream signaling pathways.
Compilation of evidence for PDGF's involvement in embryonal development, wound healing, atherosclerosis, and cancer.

Conclusions:

PDGF is a crucial regulator of cellular proliferation and differentiation.
Dysregulation of PDGF signaling contributes to the pathogenesis of several diseases.
Understanding PDGF biology is vital for developing therapeutic strategies.