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No Association Between Serum Platelet-derived Growth Factor, Platelet Size, and Regression of
P M Bath1, A D Blann, G F Watts
1Blood Pressure Unit, St George's Hospital Medical School, London, SW170RE.
Insights
This study found that platelet function markers, platelet-derived growth factor (PDGF) and mean platelet volume (MPV), did not change during dietary-induced regression of coronary artery disease, suggesting they do not contribute to this process.
Area of Science:
- Cardiovascular Research
- Hematology
- Atherosclerosis
Background:
- Platelets play a role in atherosclerosis by releasing factors like platelet-derived growth factor (PDGF).
- Dietary interventions can induce regression of coronary artery disease.
Purpose of the Study:
- To investigate the role of platelet function markers, specifically PDGF and mean platelet volume (MPV), in dietary-induced regression of coronary artery disease.
Main Methods:
- The St Thomas' Atherosclerosis Regression Study (STARS) involved 74 men randomized to diet or diet with cholestyramine.
- Serum PDGF concentrations and MPV were measured and compared between treatment groups.
- Correlations between PDGF, MPV, lipid levels, and angiographic regression were analyzed.
Main Results:
- No significant differences in serum PDGF concentrations were observed between the usual care, diet, and diet plus cholestyramine groups.
- Mean platelet volume (MPV) did not differ significantly across the treatment groups.
- PDGF concentrations and MPV showed no correlation with lipid levels or angiographic indices of disease regression.
Conclusions:
- Platelet function, as assessed by PDGF and MPV, does not appear to be altered during dietary-induced regression of coronary artery disease.
- These findings suggest that platelet function, measured by these markers, may not contribute to the regression of coronary artery disease achieved through diet.
Abstract:
Platelets are involved in atherogenesis, partly through the release of smooth muscle cell mitogens and chemoattractants such as platelet-derived growth factor (PDGF). The St Thomas' Atherosclerosis Regression Study (STARS) demonstrated that a cholesterol-lowering diet induced angiographic regression of coronary artery disease in 74 men. Serum PDGF concentrations were not different at the end of the study between patients randomised to receive diet, with or without cholestyramine: usual care (UC) median 53.6 pM (interquartile range 15.3), diet (D) 60.0 pM (29.7), diet and cholestyramine (DC) 51.5 pM (13.0), 2p = 0.23. Similarly, mean platelet volume (MPV), a marker of platelet function, did not differ between the three groups: UC 8.0 fl (1.1), D 8.6 fl (0.8), DC 9.0 fl (1.4), 2p = 0.16. PDGF concentrations and MPV did not correlate with lipid concentrations or angiographic indices of regression. These findings suggest that platelet function, as measured by PDGF and MPV, does not change during, or contribute to, dietary-induced regression of coronary artery disease.
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