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The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...

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Related Experiment Video

Updated: Jun 7, 2026

Compact Lens-less Digital Holographic Microscope for MEMS Inspection and Characterization

Compact Lens-less Digital Holographic Microscope for MEMS Inspection and Characterization

Published on: July 5, 2016

Digital microscopy: past, present, and future.

Cyrus V Hedvat¹

¹Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. hedvatc@mskcc.org

Archives of Pathology & Laboratory Medicine

|November 4, 2010

Summary

Digital microscopy and whole slide imaging are transforming pathology workflows. Pathologists must engage with this rapidly developing technology to ensure optimized workflow and diagnostic accuracy.

Area of Science:

Digital pathology
Histologic image analysis
Whole slide imaging

Background:

Digital viewing of histologic images is transitioning into daily pathology practice.
Recent technological advancements overcome limitations, making widespread adoption more feasible.
Pathologist involvement is crucial for optimizing workflow and maintaining diagnostic accuracy.

Purpose of the Study:

To outline the current status of digital microscopy in pathology.
To identify key considerations for adopting whole slide imaging systems.

Main Methods:

Author's experience.
Literature review.

Main Results:

Digital microscopy is a vital tool for surgical pathologists.

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Patterned Photostimulation with Digital Micromirror Devices to Investigate Dendritic Integration Across Branch Points

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Last Updated: Jun 7, 2026

Compact Lens-less Digital Holographic Microscope for MEMS Inspection and Characterization

Compact Lens-less Digital Holographic Microscope for MEMS Inspection and Characterization

Published on: July 5, 2016

Digital Inline Holographic Microscopy (DIHM) of Weakly-scattering Subjects

Digital Inline Holographic Microscopy (DIHM) of Weakly-scattering Subjects

Published on: February 8, 2014

Patterned Photostimulation with Digital Micromirror Devices to Investigate Dendritic Integration Across Branch Points

Patterned Photostimulation with Digital Micromirror Devices to Investigate Dendritic Integration Across Branch Points

Published on: March 2, 2011

The field is experiencing rapid technological development.

These advancements are poised to significantly alter laboratory workflows.

Conclusions:

Digital microscopy is essential for modern surgical pathology.
The technology's rapid evolution will reshape laboratory practices in the coming years.