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Selective endothelin receptor blockade in resistant hypertension: results of the DORADO trial

Guido Grassi1

  • 1University of Milano-Bicocca, Clinica Medica, Ospedale San Gerardo, Via Pergolesi 33, 20052 Monza (Milano), Italy. guido.grassi@unimib.it

Expert Opinion on Pharmacotherapy
|November 4, 2010
PubMed

Insights

Darusentan, a novel endothelin receptor blocker, effectively controlled blood pressure in over 50% of patients with resistant hypertension. However, its use was linked to significant peripheral edema and fluid retention, warranting further long-term safety evaluation.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Resistant hypertension poses a significant challenge in antihypertensive drug treatment.
  • The DORADO trial investigated darusentan, a selective endothelin receptor blocker, for patients with uncontrolled hypertension despite multiple medications.

Discussion:

  • Darusentan demonstrated efficacy in lowering both clinical and ambulatory blood pressure in over 50% of participants.
  • A notable concern is the high incidence of peripheral edema and fluid retention associated with darusentan, impacting its safety and tolerability profile.

Key Insights:

  • Selective endothelin receptor blockade with darusentan shows promise for treating resistant hypertension.
  • Peripheral edema and fluid retention are significant side effects requiring careful consideration.

Outlook:

  • Further long-term studies are essential to fully assess the safety and efficacy of darusentan.
  • The potential benefits of darusentan must be weighed against its side effect profile in clinical practice.

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