Sialic Acid: its importance to platelet function in health and disease

Platelets are known to contain sialic acid, most of which resides on glycoprotein carbohydrate side-chains. A large proportion of the platelet sialic acid is neuraminidase-labile. The sialic acid of human platelets is of the N-acetyl neuramininic acid type and is implicated in platelet functional events, such as aggregation and adhesion as well as contributing to the platelet's electrophoretic mobility. In this respect the platelet has an overall electronegative charge which is predominately the result of the carboxyl group of the sialic acid moiety. Platelet subpopulations have been isolated with differing amounts of sialic acid and cleavage of platelet sialic acid by neuraminidase is associated with loss of platelets from the circulation. This has relevance to platelet aging in vivo where removal of platelet sialic acid may reveal 'senescence antigens' which could facilitate platelet 'uptake' by the reticuloendothelial system. The importance of platelet sialic acid status has been described in certain platelet disorders such as some thrombocytopenias as well as particular disease states including malignancies and atherosclerosis.