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Related Concept Videos

Radical Autoxidation01:20

Radical Autoxidation

The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Bioactivation and Tissue Toxicity01:25

Bioactivation and Tissue Toxicity

Bioactivation is a metabolic process that transforms less reactive substances into highly reactive metabolites, initiating tissue toxicity. This transformation can lead to various toxic effects, including carcinogenesis and teratogenesis. Reactive metabolites are classified into two main types: electrophiles and free radicals.Electrophiles are electron-deficient species and are produced primarily by the enzyme cytochrome P-450 during the metabolism of compounds containing carbon, nitrogen, or...
Drug Metabolism: Phase I Reactions01:17

Drug Metabolism: Phase I Reactions

A phase I reaction is a biochemical process that introduces a functionally reactive polar group to a substance. This transformation predominantly occurs in the liver, facilitated by the cytochrome P450 system of hemoproteins situated in the lipophilic endoplasmic reticulum of cells. The metabolite generated through this process can have varying polarities. If it is sufficiently polar, it can be easily excreted in the urine due to its water compatibility. However, if the metabolite is nonpolar,...
Peroxisomes01:24

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
Peroxisomes01:24

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...

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Related Experiment Video

Updated: Jun 7, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Ezetimibe and reactive oxygen species.

Minako Yamaoka-Tojo1, Taiki Tojo, Naonobu Takahira

  • 1Department of Rehabilitation, Kitasato University School of Allied Health Sciences, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan. myamaoka@med.kitasato-u.ac.jp

Current Vascular Pharmacology
|November 4, 2010
PubMed
Summary
This summary is machine-generated.

Ezetimibe effectively lowers low-density lipoprotein (LDL)-cholesterol, offering an alternative for patients not reaching goals with statins alone. This review explores ezetimibe

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Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay
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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

High Throughput Screening Assessment of Reactive Oxygen Species (ROS) Generation using Dihydroethidium (DHE) Fluorescence Dye
05:16

High Throughput Screening Assessment of Reactive Oxygen Species (ROS) Generation using Dihydroethidium (DHE) Fluorescence Dye

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Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay
06:19

Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay

Published on: May 12, 2020

Area of Science:

  • Pharmacology
  • Cardiovascular Medicine
  • Oxidative Stress Biology

Background:

  • Hypercholesterolemia management often involves statins, which inhibit cholesterol synthesis but can have dose-limiting side effects like rhabdomyolysis.
  • Achieving guideline-recommended low-density lipoprotein (LDL)-cholesterol levels can be challenging with statin monotherapy alone.
  • Oxidative stress, driven by reactive oxygen species (ROS), plays a critical role in atherosclerosis development and progression.

Purpose of the Study:

  • To review the atheroprotective effects of ezetimibe in vasculature.
  • To discuss the mechanisms by which ezetimibe may counteract ROS-induced pro-atherosclerotic conditions.
  • To highlight ezetimibe's potential as a therapeutic option for managing hypercholesterolemia and preventing atherosclerosis.

Main Methods:

  • Literature review of studies on ezetimibe's effects on cholesterol metabolism and vascular health.
  • Analysis of research investigating the role of oxidative stress in atherosclerosis.
  • Synthesis of findings on ezetimibe's impact on reactive oxygen species (ROS) and related pathways.

Main Results:

  • Ezetimibe is a potent inhibitor of cholesterol absorption, approved for hypercholesterolemia treatment.
  • Ezetimibe demonstrates efficacy in lowering LDL-cholesterol, both as monotherapy and in combination with statins.
  • Emerging evidence suggests ezetimibe possesses atheroprotective properties by potentially mitigating oxidative stress and its vascular consequences.

Conclusions:

  • Ezetimibe offers a valuable therapeutic strategy for patients with hypercholesterolemia, particularly those who cannot achieve LDL-cholesterol goals with statins.
  • Ezetimibe's potential to improve ROS-induced pro-atherosclerotic conditions warrants further investigation for its vascular protective mechanisms.
  • Ezetimibe may play a significant role in managing atherosclerosis by addressing both cholesterol levels and oxidative stress.