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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

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A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease
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CaGrid Workflow Toolkit: a Taverna based workflow tool for cancer grid.

Wei Tan1, Ravi Madduri, Alexandra Nenadic

  • 1Computation Institute, University of Chicago and Argonne National Laboratory, Chicago, IL, USA. wtan@mcs.anl.gov

BMC Bioinformatics
|November 4, 2010
PubMed
Summary

The caGrid Workflow Toolkit extends Taverna to simplify building and running cancer research workflows. This tool integrates over 140 services, enhancing data access and analysis in bioinformatics.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Cancer Research

Background:

  • Web services and workflow technology automate data pipelines in biological and medical research.
  • Cancer Biomedical Informatics Grid (caBIG) and its caGrid infrastructure facilitate sharing of cancer research resources.
  • Scientific workflows are crucial for orchestrating services in caBIG for in-silico research.

Purpose of the Study:

  • To develop a solution for composing and coordinating isolated services within the caGrid infrastructure.
  • To ease the building and execution of caGrid workflows for cancer researchers.

Main Methods:

  • Extended the Taverna workflow system to create the caGrid Workflow Toolkit.
  • Integrated web service technology and a plug-in architecture for broad compatibility.
  • Provided support for service discovery, composition, orchestration, data access, and secure invocation.

Main Results:

  • The caGrid Workflow Toolkit simplifies the creation and execution of caGrid workflows.
  • Users gain access to over 140 services, including data and analytical tools.
  • Features include data discovery, query, transfer, security, state management, and workflow sharing.

Conclusions:

  • The caGrid Workflow Toolkit offers a comprehensive solution for integrating disparate caGrid services.
  • The toolkit enhances accessibility to cancer research resources and facilitates collaborative research.
  • The solution is adaptable for other service-computing infrastructures using similar technologies.