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Use of MTX in the elderly and in patients with compromised renal function
1Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90025-1670, USA.
Abstract:
The absorption and distribution of MTX are unchanged in the elderly compared to younger RA patients, while both metabolism and renal/biliary excretion of MTX may be affected by age and should be considered when using this drug. Neither haemodialysis nor peritoneal dialysis effectively clears MTX, although high-flux dialysis may prove to be effective. The efficacy of MTX is equivalent in the young and elderly. The adverse event profile reveals a higher frequency of GI, lower and haematological toxicity in older patents, although the overall profile is not qualitatively different.
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