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Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Structure of Lipids03:38

Structure of Lipids

Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic birds and...
Structure of Lipids03:38

Structure of Lipids

Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic birds and...
Structure of Lipids03:38

Structure of Lipids

Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic birds and...
Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
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Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich with the analogy of...

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Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
10:12

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol

Published on: March 25, 2020

A structurally relevant coarse-grained model for cholesterol.

K R Hadley1, C McCabe

  • 1Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, Tennessee, USA.

Biophysical Journal
|November 4, 2010
PubMed
Summary
This summary is machine-generated.

This study introduces a new coarse-grained model for cholesterol, crucial for biological membranes. The model accurately captures cholesterol's unique features, enabling the study of its self-assembly and crystalline structures.

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Last Updated: Jun 7, 2026

Enrichment of Mammalian Tissues and Xenopus Oocytes with Cholesterol
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Area of Science:

  • Computational biology
  • Biophysics
  • Materials science

Background:

  • Atomistic simulations are vital for studying biological membranes, including lipid systems with cholesterol.
  • Simulating self-assembly of mixed lipid systems is computationally expensive for atomistic models.
  • Existing coarse-grained cholesterol models often neglect key functional molecular features.

Purpose of the Study:

  • To develop a novel coarse-grained model for cholesterol that preserves its unique molecular characteristics.
  • To investigate the self-assembly dynamics and crystalline structures of cholesterol in biological membranes.
  • To assess the impact of retaining specific molecular features in coarse-grained models for accurate structural representation.

Main Methods:

  • Development of a new coarse-grained model for cholesterol.
  • Exploration of two distinct levels of coarse-graining.
  • Investigation of molecular feature retention in coarse-grained model development.

Main Results:

  • The proposed coarse-grained cholesterol model successfully retains essential molecular features.
  • The model facilitates the study of cholesterol's self-assembly processes.
  • The research highlights the importance of specific molecular features for accurate structural simulations.

Conclusions:

  • A new, improved coarse-grained model for cholesterol has been developed.
  • This model enables atomistic-level insights into cholesterol's role in membrane structure and self-assembly.
  • The findings underscore the necessity of molecular detail in coarse-grained simulations for biological systems.