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[Structure revision of triptophenolide].

D F Yu1, B H Hu, G P Chen

  • 1Wuhan General Hospital.

Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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Triptophenolide, isolated from Tripterygium wilfordii roots, demonstrates significant anti-inflammatory and immunosuppressive effects in animal models. This compound inhibits lymphocyte and IgG production, reducing edema and altering complement levels.

Area of Science:

  • Natural Products Chemistry
  • Pharmacology
  • Immunology

Context:

  • Tripterygium wilfordii Hook. f. is a traditional medicinal plant.
  • Diterpenoid-lactones are a class of natural compounds with diverse biological activities.
  • Understanding the chemical constituents and pharmacological properties of T. wilfordii is crucial for its therapeutic application.

Purpose:

  • To isolate and elucidate the structure of a compound from Tripterygium wilfordii roots.
  • To evaluate the pharmacological effects of the isolated compound, triptophenolide, on immune responses and inflammation.

Summary:

  • A diterpenoid-lactone, triptophenolide (C20H24O3), was isolated from the ethyl acetate extract of Tripterygium wilfordii roots with a yield of 0.025%.
  • Its structure was confirmed through comprehensive spectral analysis (UV, IR, MS, 1HNMR, 13CNMR) and X-ray crystallography, identifying it as a known compound with a revised structure.

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  • Triptophenolide exhibited significant immunosuppressive activity by inhibiting lymphocyte and immunoglobulin G (IgG) production in mice and rats (P < 0.01).
  • The compound also demonstrated potent anti-inflammatory effects, significantly inhibiting ear edema induced by dimethyl benzene and croton oil in rodent models (P < 0.01 and P < 0.05, respectively).
  • Administration of triptophenolide led to an increase in total complements in blood serum and a reduction in adrenal vitamin C content in mice.

    • Impact:

    • Triptophenolide possesses significant immunosuppressive and anti-inflammatory properties, suggesting potential therapeutic applications.
    • The findings contribute to the understanding of the pharmacological mechanisms of Tripterygium wilfordii.
    • Further research into triptophenolide could lead to the development of novel anti-inflammatory or immunosuppressive agents.