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Related Experiment Video

Updated: Jun 7, 2026

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention
11:01

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention

Published on: September 18, 2015

Mesh covered stent in ST-segment elevation myocardial infarction.

Dariusz Dudek1, Artur Dziewierz, Łukasz Rzeszutko

  • 1Department of Interventional Cardiology, Jagiellonian University Medical College, Krakow, Poland. mcdudek@cyf-kr.edu.pl

Eurointervention : Journal of Europcr in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
|November 4, 2010
PubMed
Summary

The MGuard stent effectively prevents distal embolisation in ST-segment elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI). This bare metal stent is safe and highly effective, warranting further randomized trials.

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Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • Distal embolisation of thrombus and plaque fragments is a risk during percutaneous coronary intervention (PCI).
  • The MGuard stent, a bare metal stent with an external polymer mesh sleeve, is designed to mitigate this risk.
  • Primary PCI for ST-segment elevation myocardial infarction (STEMI) requires effective embolic protection.

Purpose of the Study:

  • To evaluate the clinical feasibility, safety, and performance of the MGuard stent.
  • To assess the MGuard stent's efficacy in preventing distal embolisation during primary PCI for STEMI.

Main Methods:

  • A multicentre, prospective, single-arm study involving 60 STEMI patients.
  • Stent implantation was performed within 12 hours of STEMI onset.
  • Key outcome measures included TIMI flow, myocardial blush grade, ST-segment resolution, and distal embolisation events.

Main Results:

  • 90.0% of patients achieved final TIMI grade 3 flow.
  • 73.3% had myocardial blush grade 3, and 61.4% showed complete ST-segment resolution.
  • Distal embolisation occurred in 5.0% of cases, with a low 6-month major adverse cardiac event rate of 1.7%.

Conclusions:

  • MGuard stent implantation is safe and highly effective in STEMI patients.
  • The stent demonstrates promising results in reducing distal embolisation.
  • A larger randomized trial is recommended to confirm these clinical endpoints.