Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Biological Effects of Radiation

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...

Radiation: Applications

Radiation: Applications

The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

Absorption of Radiation

Absorption of Radiation

The rate of heat transfer by emitted radiation is described by the Stefan-Boltzmann law of radiation:

Mutations

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical Research in Community Oncology: Advancing Cancer Care Through Localized Clinical Trials.

JCO oncology practice·2026

Same author

First-in-human, phase 1, open-label study of alomfilimab, an anti-ICOS antibody, as a single agent and in combination with anti-PD-L1 in advanced malignancies.

Journal for immunotherapy of cancer·2026

Same author

Plain language summary of the LOGIC 2 study: Encorafenib, binimetinib, plus a third drug for people with BRAF V600-mutant melanoma.

Future oncology (London, England)·2026

Same author

Howard A. "Skip" Burris III, MD: an oncology pioneer reflects on patients, progress, and purpose.

The American journal of managed care·2026

Same author

The Bi-steric, mTORC1-Selective Inhibitor, RMC-5552, in Advanced Solid Tumors: A Phase 1 Trial.

Clinical cancer research : an official journal of the American Association for Cancer Research·2025

Same author

ctDNA Analysis in ERBB2-Amplified Colorectal Cancer: Biomarker Analysis of the MyPathway Trial.

Clinical cancer research : an official journal of the American Association for Cancer Research·2025

Search research articles

Related Experiment Video

Updated: Jun 7, 2026

Live Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids

Live Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids

Published on: April 5, 2024

Radiation recall with anticancer agents.

Howard A Burris¹, Jane Hurtig

¹Sarah Cannon Research Institute, Nashville, TN 37203, USA. Howard.Burris@scresearch.net

|November 4, 2010

Summary

Radiation recall is an inflammatory reaction in previously irradiated skin triggered by chemotherapy. Awareness and a longer interval between radiation and chemotherapy may minimize this poorly understood phenomenon.

Area of Science:

Oncology
Pharmacology

Background:

Radiation recall is an acute inflammatory reaction in previously irradiated tissues.
It occurs when chemotherapy agents are administered after radiotherapy, often poorly understood.

Observation:

Diverse anticancer drugs, including anthracyclines (doxorubicin), taxanes (docetaxel, paclitaxel), and antimetabolites (gemcitabine, capecitabine), have been linked to radiation recall.
Data primarily from case reports limit understanding of true incidence and predictive factors.

Findings:

Radiation recall reactions are drug-specific and unpredictable for individual patients.
No identifiable drug characteristics predict radiation recall; it can occur with any drug class post-radiotherapy.

Implications:

More Related Videos

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Published on: July 27, 2022

Related Experiment Videos

Last Updated: Jun 7, 2026

Live Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids

Live Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids

Published on: April 5, 2024

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Published on: July 27, 2022

Increased awareness is crucial for early diagnosis and management of radiation recall.

Minimizing risk may involve extending the interval between radiotherapy completion and chemotherapy initiation.