Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early years,...
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Venous thromboembolism after penile cancer surgery: a UK PeCaN study.

BJU international·2026
Same author

Emergency hospital admissions while on an elective waiting list in England: an observational study using administrative data.

The British journal of surgery·2026
Same author

The goals and needs of qualitative research in sexual medicine: recommendations from the Fifth International Consultation on Sexual Medicine (ICSM 2024).

Sexual medicine reviews·2025
Same author

Evaluating the impact of a urethral reconstruction fellowship on urethral stricture disease management at a regional hospital.

Translational andrology and urology·2025
Same author

The surgical technique and protocol for dynamic sentinel node biopsy for penile cancer at a Southeast Asian regional hospital.

Translational andrology and urology·2024
Same author

Methenamine hippurate compared with antibiotic prophylaxis to prevent recurrent urinary tract infections in women: the ALTAR non-inferiority RCT.

Health technology assessment (Winchester, England)·2022
Same journal

Bladder Foreign Body of Gastrointestinal Origin: A Case Report and Literature Review.

Archivos espanoles de urologia·2026
Same journal

Real-Time Shear Wave Elastography Combined With MRI-Ultrasound Cognitive Fusion Targeted Biopsy for Repeat Prostate Biopsy.

Archivos espanoles de urologia·2026
Same journal

Evaluating a DeepSeek-Based Case-Based Learning Approach for Teaching the Emergency Management of Urosepsis to Nursing Students.

Archivos espanoles de urologia·2026
Same journal

Association of Fibrosis-Related Gene Expression Profiles in Benign Ureteral Stricture Tissue With Restenosis After Ureteroplasty.

Archivos espanoles de urologia·2026
Same journal

Retrospective Comparison of Transurethral Prostatic Columnar Water Balloon Dilation and Pharmacotherapy for Moderate-to-Severe Benign Prostatic Hyperplasia: Efficacy, Safety and Compliance.

Archivos espanoles de urologia·2026
Same journal

Analysis of the Effect of Stepwise Refined Nursing on the Severity of Ureteral Stent-Related Symptom Clusters After Flexible Ureteroscopic Lithotripsy.

Archivos espanoles de urologia·2026
See all related articles

Related Experiment Video

Updated: Jun 7, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Oral therapy for erectile dysfunction.

Ian Eardley1

  • 1Department of Urology, St James University Hospital, Leeds, England.

Archivos Espanoles De Urologia
|November 4, 2010
PubMed
Summary
This summary is machine-generated.

Oral medications, including phosphodiesterase type 5 (PDE5) inhibitors like sildenafil, tadalafil, and vardenafil, are effective first-line treatments for erectile dysfunction, offering good safety and tolerability.

Related Experiment Videos

Last Updated: Jun 7, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Area of Science:

  • Urology
  • Pharmacology
  • Men's Health

Background:

  • Erectile dysfunction (ED) is a common condition affecting men's health.
  • Oral therapy has emerged as a primary treatment modality for ED.

Purpose of the Study:

  • To systematically review published literature on oral therapies for erectile dysfunction.
  • To assess the efficacy, tolerability, and safety of available oral ED treatments.

Main Methods:

  • Systematic literature review using Medline and comparable databases.
  • Inclusion of only peer-reviewed, published articles; exclusion of abstract-only data.

Main Results:

  • Four oral drugs are available: three phosphodiesterase type 5 (PDE5) inhibitors (sildenafil, tadalafil, vardenafil) and apomorphine.
  • PDE5 inhibitors enhance smooth muscle relaxation for erections; apomorphine acts centrally.
  • Evidence supports the efficacy, tolerability, and safety of these oral agents; PDE5 inhibitors show comparable efficacy.

Conclusions:

  • Oral therapy is the recommended first-line treatment for most men with erectile dysfunction.
  • Commercially available oral drugs demonstrate significant efficacy, tolerability, and safety profiles.