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Association between acute corneal hydrops in patients with keratoconus and mitral valve prolapse

Zahra Rabbanikhah1, Mohammad Ali Javadi, Pooya Rostami

  • 1Shahid Beheshti University of Medical Sciences, Tehran, Iran. labbafi@hotmail.com

Cornea
|November 4, 2010
PubMed

Insights

Patients with keratoconus (KCN) experiencing corneal hydrops show a strong association with mitral valve prolapse (MVP). This suggests a potential link requiring further cardiac evaluation in KCN patients with hydrops.

Area of Science:

  • Ophthalmology
  • Cardiology
  • Genetics

Background:

  • Keratoconus (KCN) is a progressive thinning of the cornea.
  • Corneal hydrops are acute fluid accumulation within the cornea.
  • Mitral valve prolapse (MVP) is a common cardiac condition.

Purpose of the Study:

  • To investigate the potential association between corneal hydrops in patients with keratoconus (KCN) and mitral valve prolapse (MVP).

Main Methods:

  • A case-control study was conducted with 32 KCN patients with corneal hydrops (cases) and 128 controls.
  • Cardiac examination including echocardiography was performed for all participants.
  • MVP diagnosis followed established criteria (Perloff et al).

Main Results:

  • MVP prevalence was significantly higher in the case group (65.6%) compared to controls (9%, P < 0.001).
  • Patients with corneal hydrops had an odds ratio of 26.7 for MVP.
  • Adjusted analyses confirmed a higher odds ratio for MVP in the case group.

Conclusions:

  • A significant correlation exists between corneal hydrops secondary to KCN and MVP.
  • Further cardiac evaluation is recommended for KCN patients presenting with corneal hydrops to assess mitral valve status.
Abstract

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