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Related Concept Videos

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
Inhaled Medications01:23

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Related Experiment Video

Updated: Jun 7, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

Can inhaled corticosteroids prevent asthma exacerbations?

Dhananjay Desai1, Salman Siddiqui, Christopher Brightling

  • 1Department of Infection, Inflammation and Immunity, Institute of Lung Health, University of Leicester, Leicester, UK.

Current Opinion in Pulmonary Medicine
|November 4, 2010
PubMed
Summary

Inhaled corticosteroids are the primary anti-inflammatory treatment for asthma, effectively reducing exacerbations. Identifying eosinophilic inflammation aids in predicting steroid response and guiding asthma management.

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Last Updated: Jun 7, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Area of Science:

  • Pulmonology
  • Immunology
  • Pharmacology

Background:

  • Asthma exacerbations are unpredictable, leading to significant morbidity, mortality, and healthcare costs.
  • Inhaled corticosteroids (ICS) are a cornerstone therapy, improving quality of life and reducing exacerbation frequency.

Purpose of the Study:

  • To review the current understanding of asthma exacerbations and the role of inhaled corticosteroids.
  • To highlight the heterogeneity of asthma exacerbations and the importance of phenotyping airway inflammation.

Main Methods:

  • Review of current literature on asthma exacerbations and inhaled corticosteroid therapy.
  • Analysis of noninvasive monitoring techniques for airway inflammation phenotyping.
  • Evaluation of treatment strategies targeting eosinophilic airway inflammation.

Main Results:

  • Asthma exacerbation aetiopathology is heterogeneous, with a subgroup of patients exhibiting eosinophilic inflammation who respond well to steroids.
  • Corticosteroid strategies targeting eosinophilic inflammation consistently reduce exacerbations.
  • The impact of corticosteroids on the natural history of asthma remains less certain.

Conclusions:

  • While future research aims to uncover new therapeutic targets for asthma exacerbations, inhaled corticosteroids remain the first-line anti-inflammatory treatment.
  • Personalized medicine approaches, guided by inflammation phenotyping, may optimize asthma management.
  • Continued investigation into the mechanisms underlying asthma exacerbations is crucial for advancing treatment options.