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Secondary hematologic neoplasm after intravesical chemotherapy for superficial bladder carcinoma
P Sonneveld1, K H Kurth, A Hagemeyer
1Department of Hematology, University Hospital Rotterdam, Dijkzigt, The Netherlands.
Cancer
|January 1, 1990
Abstract:
Two cases are reported of patients who developed a hematologic malignancy several years after intravesical chemotherapy of superficial bladder cancer with etoglucid, doxorubicin, and mitomycin C. In one patient, karyotypic abnormalities (-5, 7q-) typical of a therapy induced malignancy were associated with rapid progression of a refractory anemia with excess blasts in transformation to an acute non-lymphocytic leukemia. Intravesical chemotherapy may be associated with a risk of secondary malignancy.