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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

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Related Experiment Video

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Automated Joint Space Detection Improves Bone Segmentation Accuracy
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Published on: November 28, 2025

Emerging MRI methods in rheumatoid arthritis.

Camilo G Borrero1, James M Mountz, John D Mountz

  • 1Department of Radiology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA.

Nature Reviews. Rheumatology
|November 4, 2010
PubMed
Summary

New MRI techniques now assess rheumatoid arthritis (RA) joint changes and disease activity. This allows for better monitoring of synovium, bone, and cartilage, aiding treatment response evaluation.

Area of Science:

  • Radiology
  • Rheumatology
  • Medical Imaging

Background:

  • Rheumatoid arthritis (RA) involves synovial hyperplasia, bone changes, and cartilage degradation.
  • Assessing disease activity and structural damage is crucial for RA management.
  • Traditional methods have limitations in evaluating dynamic pathological processes.

Purpose of the Study:

  • To review advances in Magnetic Resonance Imaging (MRI) for rheumatoid arthritis (RA).
  • To highlight MRI's role in assessing both static and dynamic pathological changes in RA.
  • To discuss the application of new MRI techniques in RA diagnosis and monitoring.

Main Methods:

  • Review of current and emerging MRI techniques for RA assessment.
  • Focus on quantitative MRI for synovitis, bone marrow edema, erosions, and cartilage changes.

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  • Comparison of MRI sensitivity and specificity with other imaging modalities.

    • Main Results:

    • MRI can detect early RA signs like synovitis, bone marrow edema, and subchondral cysts.
    • Advanced MRI techniques enable quantitative assessment of synovitis, bone marrow edema, and cartilage composition.
    • MRI demonstrates high sensitivity for detecting early bone erosions, comparable to CT.

    Conclusions:

    • New MRI techniques offer comprehensive assessment of RA, including disease activity and structural damage.
    • MRI facilitates early detection and monitoring of pathological changes in synovium, bone, and cartilage.
    • These advancements improve the evaluation of treatment response in rheumatoid arthritis patients.