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Related Experiment Video

Updated: Jun 7, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
07:15

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

Published on: July 28, 2020

Does delayed reexcision affect outcome after unplanned excision for soft tissue sarcoma?

Ilkyu Han1, Hyun Guy Kang, Seung Chul Kang

  • 1Department of Orthopaedic Surgery, Seoul National University College of Medicine, 101 Daehangno, Jongno-gu, Seoul, 110-744, Korea.

Clinical Orthopaedics and Related Research
|November 4, 2010
PubMed
Summary

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Delaying reexcision after soft tissue sarcoma removal does not significantly impact patient survival or local recurrence. These findings suggest that any negative effects of delayed surgery are likely minor for patients with soft tissue sarcoma.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Sarcoma Research

Background:

  • Unplanned excision of soft tissue sarcomas often necessitates reexcision for adequate margins.
  • A common assumption is that delaying definitive surgery negatively impacts survival and local recurrence.
  • However, existing literature lacks clear evidence to support this assumption.

Purpose of the Study:

  • To investigate whether the timing of reexcision surgery affects patient survival and local recurrence rates.
  • To evaluate the impact of delayed definitive surgery after unplanned excision of soft tissue sarcoma.

Main Methods:

  • Retrospective review of 104 patients with localized soft tissue sarcoma undergoing definitive surgery after unplanned excision.
  • Data collected included patient demographics, tumor diagnosis, location, time to definitive surgery, and follow-up duration.

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  • Statistical analysis to correlate time to surgery with survival and local control outcomes.
  • Main Results:

    • The 5-year disease-specific survival rate was 88%, and the 5-year local control rate was 74%.
    • No significant difference in disease-specific survival or local recurrence was observed based on the interval to definitive surgery.
    • Higher histologic grade and larger tumor size were independent predictors of disease-specific survival; positive margins and larger tumor size predicted local control.

    Conclusions:

    • The study suggests that any influence of delayed definitive surgery for soft tissue sarcoma is likely of minor clinical significance.
    • These findings challenge the assumption that prompt reexcision is critical for favorable outcomes.