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Updated: Jun 7, 2026
Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
Published on: August 3, 2021
[Preparation of multivariant-phospholipid complex of Ginkgo biloba extract]
Zhipeng Chen1, Jun Sun, Dan Liu
1Jiangsu Key Laboratory of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210029, China. czpcpu2000@hotmail.com
Objective:
To prepare Ginkgo biloba extract multivariant-phospholipid complex(MGBP) and improve the vitro dissolution of ginkgo total flavonoids by adding another water-soluble carrier in phospholipid complex.
Method:
MGBP was prepared using solvent evaporation method with Poloxamer-188 as the carrier and the multivariant complex was analyzed by DSC and X-diffraction technique. The physicochemical properties of the MGBP we also studied, including apparent oil-water distribution coefficients in different pH aqueous solution and its release in vitro.
Result:
The in vitro dissolution of ginkgo total flavonoids was significantly increased while the apparent oil-water distribution coefficient was improved after been made into multivariant-phospholipid complex.
Conclusion:
The preparation technology of MGBP is simple and economic. MGBP can significantly increase the vitro dissolution of ginkgo total flavonoids and improve oil-water distribution coefficients, which can be the reference for the bioavailability in vivo in the further researches.
