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[Optimization of extraction conditions for semi-bionic extraction of Guizhi Fuling pill decoction by uniform design]
Fang Li1, Zhaowang Zhang, Xiumei Sun
1Shanxi Provincial Academy of Traditional Chinese Medicine, Xi'an 710003, China. amelia@126.com
Objective:
To optimize the extraction conditions for semi-bionic extraction of Guizhi Fuling pill decoction.
Method:
The best extraction condition of the semi-bionic extraction for Guizhi Fuling pill decoction was optimized by uniform design was optimized with paeoniflorin, cinnamic acid, laetrile, pachymic acid, total polysaccharose and dry extract as the indexes.
Result:
The optimized extraction condition is that extracting for 3 times with solvent pH values of 4.98, 7.35 and 8.00, respectively, and the total extracting time was 4.99 h.
Conclusion:
In consideration of manufacturing fact, the pH value of thrice extractions is set at 5.0, 7.5, 8.0 respectively, and the extracting time is 2.0, 1.5, 1.5 h in turn.
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