Related Experiment Video
Updated: Jun 7, 2026
Formation of Human Periodontal Ligament Cell Spheroids on Chitosan Films
Published on: June 19, 2019
[Research progress of cells and cell-transplantation methods for periodontal tissue engineering]
1School of Dentistry, Tianjin Medical University, Tianjin 300070, PR China.
Objective:
To introduce the cells and cell-transplantation methods for periodontal tissue engineering.
Methods:
Recent literature about application of cell-based therapy in periodontal tissue engineering was extensively reviewed, the cells and cell-transplantation methods were investigated.
Results:
Mesenchymal stem cells were important cell resources for periodontal tissue engineering, among which periodontal ligament stem cells were preferred. Bone marrow mesenchymal stem cells had several disadvantages in clinical application, and adipose-derived stem cells might be a promising alternative; different transplantation methods could all promote periodontal regeneration to some extent. Single-cell suspension injection could only promote a little gingival regeneration, and tissue engineered scaffolds still needed some improvement to be used in periodontal regeneration, while cell sheet technique, with great cell loading ability and no need of scaffolds, could promote regeneration of cementum, periodontal ligament, and alveolar bone under different conditions.
Conclusion:
Multipotent stem cells are fit to be used in periodontal tissue engineering; improvement of cell-transplantation methods will further promote periodontal regeneration.
