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Related Concept Videos

Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...

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Related Experiment Video

Updated: Jun 7, 2026

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei
09:02

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei

Published on: February 17, 2014

Disseminated tuberculosis: interesting hematological observations.

R Avasthi1, D Mohanty, S C Chaudhary

  • 1Department of Medicine, University College of Medical Sciences, (University of Delhi) and GTB Hospital, Delhi 95.

The Journal of the Association of Physicians of India
|November 5, 2010
PubMed
Summary
This summary is machine-generated.

Disseminated tuberculosis can cause severe hematological issues like pancytopenia. Early diagnosis, aided by bone marrow examination, is crucial for effective antitubercular treatment.

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Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay
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Published on: September 16, 2012

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An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei
09:02

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Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay
14:45

Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay

Published on: September 16, 2012

Area of Science:

  • Hematology
  • Infectious Diseases
  • Neurology

Background:

  • Disseminated tuberculosis presents diversely, including fever, organomegaly, and neurological symptoms.
  • Hematological abnormalities like pancytopenia are rare but significant presentations.

Observation:

  • A case presented with fever, vomiting, and altered sensorium, suggestive of meningitis.
  • Neuroimaging confirmed meningitis, but cerebrospinal fluid findings were equivocal.
  • The patient exhibited severe pancytopenia, hemophagocytosis, and bone marrow granulomas.

Findings:

  • Bone marrow examination revealed epithelioid cell granulomas with Langhans' giant cells and necrosis, confirming tuberculosis.
  • Peripheral smear showed severe pancytopenia and hemophagocytosis.
  • The patient responded well to four-drug antitubercular therapy (RHZE).

Implications:

  • This case underscores the importance of hematological findings in diagnosing disseminated tuberculosis.
  • Hematological evaluation can aid in confirming tuberculosis when other diagnostic methods are inconclusive.
  • Prompt diagnosis and treatment based on hematological parameters lead to favorable outcomes.