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Pertussis in adolescents and its prevention using Tdap vaccination

ChrisAnna Marie Mink1, Sylvia Hsin-Hue Yeh

  • 1Department of Pediatrics, Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA. cmink@labiomed.org

Adolescent Medicine: State of the Art Reviews
|November 5, 2010
PubMed

Insights

Reduced-dose pertussis vaccines (Tdap) protect adolescents and adults, reducing disease spread. This strategy aims to shield vulnerable infants from pertussis by lowering infection reservoirs in older populations.

Area of Science:

  • Immunology
  • Vaccinology
  • Public Health

Background:

  • Routine pertussis vaccination has shifted disease incidence to infants, adolescents, and adults.
  • Adolescents and adults, while experiencing less severe pertussis, act as reservoirs for infant infections.
  • Increasing pertussis incidence in older individuals necessitates targeted interventions.

Purpose of the Study:

  • To introduce reduced-dose acellular pertussis vaccines combined with diphtheria and tetanus toxoids (Tdap) for adolescents and adults.
  • To protect adolescents and adults from pertussis.
  • To reduce pertussis circulation and protect vulnerable infants.

Main Methods:

  • Development of reduced-dose acellular pertussis vaccines (Tdap).
  • Administration of Tdap boosters to adolescents and adults.
  • Monitoring of pertussis incidence and disease burden shifts.

Main Results:

  • Tdap boosters aim to protect vaccinated adolescents and adults.
  • The strategy seeks to decrease the overall circulation of pertussis.
  • The ultimate goal is to enhance protection for young infants.

Conclusions:

  • Tdap boosters are a key strategy in managing pertussis in industrialized nations.
  • Protecting adolescents and adults indirectly safeguards infants from pertussis.
  • Vaccination of older age groups is crucial for controlling infectious disease reservoirs.

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