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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
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Self-crimping, biodegradable, electrospun polymer microfibers.

Denver C Surrao1, James W S Hayami, Stephen D Waldman

  • 1Departments of Chemical Engineering, Queen's University, Kingston, ON, Canada.

Biomacromolecules
|November 5, 2010
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Summary
This summary is machine-generated.

Researchers created self-crimping poly(l-lactide-co-ε-caprolactone) fibers that mimic collagen

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Semicrystalline poly(l-lactide-co-ε-caprolactone) (P(LLA-CL)) is a biocompatible and tunable polymer.
  • Collagen fibrils in soft connective tissues exhibit a characteristic crimp pattern.
  • Mimicking natural tissue structures is crucial for effective tissue engineering scaffolds.

Purpose of the Study:

  • To develop self-crimping electrospun fibers that mimic the structure of collagen fibrils.
  • To investigate the mechanism of fiber crimping and its dependence on processing parameters.
  • To evaluate the suitability of these crimped fibers for connective tissue engineering applications.

Main Methods:

  • Electrospinning of P(LLA-CL) using a rotating wire mandrel at high collection speeds to align fibers.
  • Inducing fiber crimping by controlling the operating temperature relative to the polymer's glass-transition temperature.
  • Characterizing fiber structure, mechanical properties (stress-strain profile), and in vitro degradation.
  • Assessing fibroblast attachment, proliferation, and extracellular matrix deposition on the crimped fiber mats.

Main Results:

  • Aligned electrospun P(LLA-CL) fibers exhibited a reproducible crimp pattern upon removal from the mandrel.
  • Fiber crimping was attributed to residual stresses and the difference between operating and glass-transition temperatures.
  • Crimped fibers displayed a toe region in their stress-strain curve, similar to native collagen.
  • The crimp structure was stable during 4 weeks of in vitro degradation.
  • Fibroblasts successfully attached, proliferated, and deposited extracellular matrix on the crimped fiber scaffolds.

Conclusions:

  • Self-crimping electrospun P(LLA-CL) fibers can effectively mimic the structural characteristics of collagen fibrils.
  • The processing method allows for tunable crimp formation, offering control over fiber architecture.
  • These crimped fibers demonstrate excellent biocompatibility and support cellular activity, making them promising for connective tissue engineering.
  • The retained crimp structure and mechanical properties suggest potential for load-bearing applications in tissue regeneration.