Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nose and Nasal Cavity

Nose and Nasal Cavity

The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...

Respiratory Syncytial Virus Disease

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...

Vaccine Production

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...

Suctioning the Nasopharyngeal Airway

Suctioning the Nasopharyngeal Airway

Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A study of Chitosan and c-di-GMP as mucosal adjuvants for intranasal influenza H5N1 vaccine.

Influenza and other respiratory viruses·2012

Same author

Chitosan-based delivery systems for mucosal vaccines.

Expert opinion on drug delivery·2012

Same author

The mucosal and systemic immune responses elicited by a chitosan-adjuvanted intranasal influenza H5N1 vaccine.

Influenza and other respiratory viruses·2011

Same author

Effect of chitosan on the intranasal absorption of salmon calcitonin in sheep.

The Journal of pharmacy and pharmacology·2005

Same author

Intranasal delivery of recombinant human growth hormone (somatropin) in sheep using chitosan-based powder formulations.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2005

Same author

Effective nasal influenza vaccine delivery using chitosan.

Vaccine·2005

Search research articles

Related Experiment Video

Updated: Jun 7, 2026

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Published on: September 28, 2022

Nasal vaccine innovation.

Inderjit Jabbal-Gill¹

¹Archimedes Development Ltd., Albert Einstein Centre, Nottingham Science & Technology Park, University Boulevard, Nottingham, UK. indergill@archimedespharma.com

Journal of Drug Targeting

|November 5, 2010

Summary

This summary is machine-generated.

Intranasal vaccines offer a promising alternative administration route, enhancing convenience and safety while eliciting robust immune responses. Innovations in nasal vaccine delivery are crucial for pandemic preparedness and rapid global vaccination efforts.

More Related Videos

Intranasal Delivery of mRNA Polyplexes via Rayleigh Breakup Aerosols: An In Vitro Method for Nasal Deposition and Functional Testing

Intranasal Delivery of mRNA Polyplexes via Rayleigh Breakup Aerosols: An In Vitro Method for Nasal Deposition and Functional Testing

Published on: January 20, 2026

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)

Published on: July 31, 2021

Related Experiment Videos

Last Updated: Jun 7, 2026

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Published on: September 28, 2022

Intranasal Delivery of mRNA Polyplexes via Rayleigh Breakup Aerosols: An In Vitro Method for Nasal Deposition and Functional Testing

Intranasal Delivery of mRNA Polyplexes via Rayleigh Breakup Aerosols: An In Vitro Method for Nasal Deposition and Functional Testing

Published on: January 20, 2026

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)

Published on: July 31, 2021

Area of Science:

Vaccinology
Immunology
Pharmaceutical Sciences

Background:

The vaccine market is exploring alternative administration routes beyond traditional injections.
Intranasal vaccine delivery presents a promising avenue due to enhanced convenience, safety, and the potential for local and systemic immunity.

Purpose of the Study:

To discuss innovative strategies and challenges in intranasal vaccine development.
To highlight the market potential and regulatory considerations for nasal vaccines.

Main Methods:

Review of innovative strategies including live-attenuated vaccines, adjuvants, mucoadhesives, and particulate delivery systems.
Discussion of challenges in antigen retention, adjuvant selection, and regulatory hurdles.
Exploration of specific technologies like ChiSys(®) for enhanced nasal vaccine delivery.

Main Results:

Nasal vaccination can elicit both local and systemic immune responses, protecting at the pathogen's entry site.
Mucoadhesive technologies and appropriate adjuvants are critical for effective antigen retention and immune response.
Intranasal vaccination holds significant potential for public compliance and rapid mass vaccination during pandemics.

Conclusions:

Intranasal vaccine technology offers significant advantages in convenience, safety, and immunogenicity.
Overcoming challenges in antigen delivery and adjuvant selection is key to realizing the full potential of nasal vaccines.
The development of effective intranasal vaccines is vital for future pandemic preparedness and global health security.