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Updated: Jun 7, 2026

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities
Published on: October 27, 2023
A maximum likelihood approach to joint image registration and fusion
Siyue Chen1, Qing Guo, Henry Leung
1Complex System, Inc., Calgary, Canada. chens@ucalgary.ca
This study introduces a novel maximum likelihood approach for joint image registration and fusion. This method optimizes both processes simultaneously, achieving registration accuracy close to Cramer-Rao bounds and enhancing fusion performance.
Area of Science:
- Computer Vision
- Signal Processing
- Remote Sensing
Background:
- Image registration and fusion are conventionally treated as separate estimation problems.
- Existing methods may not optimally tune registration parameters for fusion quality.
Purpose of the Study:
- To develop a unified maximum likelihood framework for joint image registration and fusion.
- To optimize registration accuracy and fusion performance simultaneously.
Main Methods:
- A maximum likelihood approach is proposed, formulating joint image registration and fusion as a single estimation problem.
- The Expectation-Maximization algorithm is employed for solving the joint optimization.
- The Cramer-Rao bound (CRB) is derived for performance analysis.
Main Results:
- Experimental evaluation using visual, IR thermal, and hyperspectral images demonstrates performance.
- The proposed method achieves mean square error for registration parameters close to the CRBs.
- Fusion performance, measured by edge preservation (Q(AB/F)), is improved compared to Laplacian pyramid fusion.
Conclusions:
- The joint optimization approach effectively enhances both image registration accuracy and fusion quality.
- The method offers a robust solution for multi-modal and multi-sensor image fusion applications.
- The proposed technique provides a significant advancement over conventional separate processing methods.
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