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Related Concept Videos

Autocrine Signaling01:01

Autocrine Signaling

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Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
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What is Cell Signaling?02:03

What is Cell Signaling?

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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
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Overview of Cell Signaling01:23

Overview of Cell Signaling

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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
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mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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Signal Transduction: Overview01:26

Signal Transduction: Overview

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Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
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Related Experiment Video

Updated: Dec 31, 2025

A Proximal Culture Method to Study Paracrine Signaling Between Cells
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A Proximal Culture Method to Study Paracrine Signaling Between Cells

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[Cell signalling and cancer].

J Robert1

  • 1Université de Bordeaux, Inserm U916, Institut Bergonié, 33076 Bordeaux cedex, France. robert@bergonie.org

Bulletin Du Cancer
|November 5, 2010
PubMed
Summary
This summary is machine-generated.

Cell signalling controls cell functions like growth and survival. Cancer hijacks these communication pathways, making it a disease of cell signalling.

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Area of Science:

  • Cellular biology
  • Molecular biology
  • Cancer biology

Context:

  • Cell signalling is the fundamental process of intercellular communication.
  • Signal transduction pathways regulate critical cellular activities including proliferation, differentiation, adhesion, motility, survival, and death.
  • Cancer cells exploit and reprogram these pathways for uncontrolled growth and metastasis.

Purpose:

  • To classify major cell signalling pathways.
  • To outline common mechanisms of intracellular and intercellular information transmission.
  • To explain how cancer cells manipulate cell signalling.

Summary:

  • Cell signalling pathways form a complex network for cell communication, regulating gene transcription and cellular functions.
  • Cancer cells hijack these pathways through genetic or epigenetic alterations, promoting their proliferation, migration, and survival.
  • Understanding these hijacked pathways is crucial for cancer research and therapeutic development.

Impact:

  • Provides a foundational understanding of cell signalling in cancer.
  • Highlights cancer as a disease of dysregulated cell communication.
  • Establishes a framework for exploring targeted cancer therapies based on signalling pathway modulation.