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Updated: Dec 31, 2025

A Proximal Culture Method to Study Paracrine Signaling Between Cells
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A Proximal Culture Method to Study Paracrine Signaling Between Cells

Published on: August 28, 2018

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[Cell signalling and cancer]

J Robert1

  • 1Université de Bordeaux, Inserm U916, Institut Bergonié, 33076 Bordeaux cedex, France. robert@bergonie.org

Bulletin Du Cancer
|November 5, 2010
PubMed

Insights

Cell signalling controls cell functions like growth and survival. Cancer hijacks these communication pathways, making it a disease of cell signalling.

Area of Science:

  • Cellular biology
  • Molecular biology
  • Cancer biology

Context:

  • Cell signalling is the fundamental process of intercellular communication.
  • Signal transduction pathways regulate critical cellular activities including proliferation, differentiation, adhesion, motility, survival, and death.
  • Cancer cells exploit and reprogram these pathways for uncontrolled growth and metastasis.

Purpose:

  • To classify major cell signalling pathways.
  • To outline common mechanisms of intracellular and intercellular information transmission.
  • To explain how cancer cells manipulate cell signalling.

Summary:

  • Cell signalling pathways form a complex network for cell communication, regulating gene transcription and cellular functions.
  • Cancer cells hijack these pathways through genetic or epigenetic alterations, promoting their proliferation, migration, and survival.
  • Understanding these hijacked pathways is crucial for cancer research and therapeutic development.

Impact:

  • Provides a foundational understanding of cell signalling in cancer.
  • Highlights cancer as a disease of dysregulated cell communication.
  • Establishes a framework for exploring targeted cancer therapies based on signalling pathway modulation.

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