Related Experiment Video

Updated: Jun 7, 2026

Experimental Generation of Carcinoma-Associated Fibroblasts (CAFs) from Human Mammary Fibroblasts
15:43

Experimental Generation of Carcinoma-Associated Fibroblasts (CAFs) from Human Mammary Fibroblasts

Published on: October 25, 2011

Roles of fibroblast growth factor receptors in carcinogenesis

Ellen Margrethe Haugsten1, Antoni Wiedlocha, Sjur Olsnes

  • 1Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway. Ellen.M.Haugsten@rr-research.no

Molecular Cancer Research : MCR
|November 5, 2010
PubMed

Insights

Fibroblast growth factor receptors (FGFR) are crucial for cell regulation. Aberrant FGFR signaling drives cancer progression through various genetic alterations, impacting tissue homeostasis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • Fibroblast growth factor receptors (FGFR) are vital for development and adult tissue homeostasis.
  • FGFR signaling regulates critical cellular functions including proliferation, survival, migration, and differentiation.
  • Dysregulation of FGFR signaling is linked to developmental disorders and numerous cancers.

Purpose of the Study:

  • To provide a comprehensive overview of FGFR alterations in human cancer.
  • To discuss the mechanisms by which FGFR deregulation contributes to cancer progression.

Main Methods:

  • Literature review of studies on FGFR alterations in human cancer.
  • Analysis of mechanisms including aberrant expression, mutations, chromosomal rearrangements, and amplifications.
  • Discussion of the functional impact of these alterations on cancer biology.

Main Results:

  • FGFRs are frequently deregulated in human cancers through diverse genetic and epigenetic mechanisms.
  • Specific FGFR alterations are associated with various cancer types and stages.
  • These alterations can activate oncogenic signaling pathways, promoting tumor growth and metastasis.

Conclusions:

  • FGFR alterations represent a significant driver of human cancer.
  • Understanding these alterations is crucial for developing targeted therapies.
  • Targeting FGFR signaling holds promise for improving cancer treatment outcomes.

More Related Videos

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

Three-dimensional Co-culture Model for Tumor-stromal Interaction08:39

Three-dimensional Co-culture Model for Tumor-stromal Interaction

Published on: February 2, 2015

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Introduction to Fibroblasts01:09

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...