Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
Penis01:29

Penis

The penis serves a dual role in sexual reproduction and urination. It consists of three main regions: the glans penis, the body, and the root, each with distinct functions and unique anatomical features.
Anatomy of the Penis
The glans penis, or the head, is the terminal part of the penis and houses the external urethral orifice, the exit point for urine and semen. Covered by the prepuce, or foreskin, the glans is noted for its sensitivity and plays a key role in sexual pleasure. The body of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A comprehensive history of injection therapy for erectile dysfunction, 1982-2023.

Sexual medicine reviews·2024
Same author

The Lost Penis Syndrome: A New Clinical Entity in Sexual Medicine.

Sexual medicine reviews·2021
Same author

Review of the Current Status of Low Intensity Extracorporeal Shockwave Therapy (Li-ESWT) in Erectile Dysfunction (ED), Peyronie's Disease (PD), and Sexual Rehabilitation After Radical Prostatectomy With Special Focus on Technical Aspects of the Different Marketed ESWT Devices Including Personal Experiences in 350 Patients.

Sexual medicine reviews·2020
Same author

[Reflexions on 50 Years of Sexual Medicine in Urology Focusing on Male Sexual Dysfunctions].

Aktuelle Urologie·2019
Same author

Current Strategies in the Management of Peyronie's Disease (PD)-Results of a Survey of 401 Sexual Medicine Experts Across Europe.

The journal of sexual medicine·2019
Same author

Penile traction therapy with the new device 'Penimaster PRO' is effective and safe in the stable phase of Peyronie's disease: a controlled multicentre study.

BJU international·2018
Same journal

Bladder Foreign Body of Gastrointestinal Origin: A Case Report and Literature Review.

Archivos espanoles de urologia·2026
Same journal

Real-Time Shear Wave Elastography Combined With MRI-Ultrasound Cognitive Fusion Targeted Biopsy for Repeat Prostate Biopsy.

Archivos espanoles de urologia·2026
Same journal

Evaluating a DeepSeek-Based Case-Based Learning Approach for Teaching the Emergency Management of Urosepsis to Nursing Students.

Archivos espanoles de urologia·2026
Same journal

Association of Fibrosis-Related Gene Expression Profiles in Benign Ureteral Stricture Tissue With Restenosis After Ureteroplasty.

Archivos espanoles de urologia·2026
Same journal

Retrospective Comparison of Transurethral Prostatic Columnar Water Balloon Dilation and Pharmacotherapy for Moderate-to-Severe Benign Prostatic Hyperplasia: Efficacy, Safety and Compliance.

Archivos espanoles de urologia·2026
Same journal

Analysis of the Effect of Stepwise Refined Nursing on the Severity of Ureteral Stent-Related Symptom Clusters After Flexible Ureteroscopic Lithotripsy.

Archivos espanoles de urologia·2026
See all related articles

Related Experiment Video

Updated: Jun 7, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

The future of erectile dysfunction (ED).

Hartmut Porst1

  • 1European Society for Sexual Medicine Standards Committee for Sexual Medicine of the International Society for Sexual Medicine, Hamburg, Germany. 20354@aol.com

Archivos Espanoles De Urologia
|November 5, 2010
PubMed
Summary
This summary is machine-generated.

Many erectile dysfunction (ED) patients don't respond to PDE 5 inhibitors alone. Lifestyle changes and combination therapies, including novel drug targets and regenerative medicine, show promise for improving ED treatment outcomes.

Related Experiment Videos

Last Updated: Jun 7, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Area of Science:

  • Urology
  • Pharmacology
  • Regenerative Medicine

Background:

  • Approximately 30-40% of patients with erectile dysfunction (ED) are non-responders to phosphodiesterase type 5 (PDE 5) inhibitor monotherapy.
  • Identifying strategies to improve treatment responsiveness is crucial for managing ED effectively.

Purpose of the Study:

  • To review current and emerging therapeutic strategies for erectile dysfunction, focusing on improving PDE 5 inhibitor responsiveness and exploring novel treatment modalities.
  • To evaluate the potential of combination therapies, lifestyle modifications, and future treatments like gene and stem cell therapy for ED.

Main Methods:

  • Literature review of studies investigating PDE 5 inhibitor responsiveness, combination therapies, and novel ED treatments.
  • Analysis of preclinical and clinical data on guanylate cyclase activators, RhoA-kinase inhibitors, immunophilin ligands, and regenerative medicine approaches.

Main Results:

  • Lifestyle modifications (physical activity, weight loss) enhance PDE 5 inhibitor responsiveness.
  • Combination therapies (e.g., PDE 5 inhibitors with L-Arginine, statins, or Yohimbine) improve efficacy.
  • Novel targets like guanylate cyclase activators, RhoA-kinase inhibitors, and immunophilin ligands show potential.
  • Gene therapy and stem cell therapy are promising future avenues for ED treatment.

Conclusions:

  • Improving PDE 5 inhibitor responsiveness can be achieved through lifestyle changes and various combination therapies.
  • Emerging therapeutic targets and regenerative medicine approaches hold significant promise for future ED treatment strategies.
  • Further research into novel drug targets and cell-based therapies is warranted to address unmet needs in ED management.